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Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency

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However, its also important to be mindful of the fact that taking too much of any vitamin or mineral can have adverse effects on the body

B12 is not a cure for clinical depression or anxiety, so persistent mood symptoms should be evaluated by a provider